New Skin Cream Highly Effective in Reducing Existing Skin Cancers in Mice
A skin cream
The discovery has researchers excited as it may have similar implications in humans as it could be added to sunscreen as a cancer-fighting
CP-31398, which is the active component of the cream, works by reactivating disabled forms of a natural tumour-suppressing protein called p53, nicknamed 'the guardian of the genome'.
The protein manages several important cellular functions, including the repair of damaged DNA, cell division and a genetically encoded auto-destruct pathway called apoptosis that kills unhealthy cells.
In over half of all human cancers, the p53 gene is mutated. Therefore, pharmaceutical companies have been looking for compounds that will be able to protect or restore p53 activity, in the hope that these might prevent or treat cancer
It was shown by the researchers in 1999, that CP-31398 restores normal activity to mutated p53 proteins in cell cultures (however its exact working is not known)
A biochemist at the University of Alabama in Birmingham, Mohammad Athar went ahead to test the compound in live animals.
Onto the skin
When the experiment ended, mice treated with CP-31398 had seven tumours on average; control mice that did not receive the drug had 16. The tumours that developed on treated mice were almost a sixth the size of tumours in control mice.
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